Why the study?
Does the hypertrophied and failing heart shift its fuel source from fatty acids to ketone bodies?
Population
Well-defined mouse models of cardiac hypertrophy and heart failure
Comparison
Metabolic profiling using quantitative… vs Normal/non-failing hearts (implied)
Design
Preclinical
Authors
Loading...
Hypothesis-generating for ketone-targeted HF therapies; leaves open translation from animal models to patients.
Does the hypertrophied and failing heart shift its fuel source from fatty acids to ketone bodies?
The failing heart shifts its energy metabolism from fatty acid oxidation to ketone body utilization, revealing a potential novel metabolic target for heart failure therapies.
Aubert et al. (2016) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: