Chronic atorvastatin exposure (10 mg/kg for 1 month) in mice led to an increase in the ultrarapid delayed rectifier potassium current in isolated ventricular cardiomyocytes.
Chronic atorvastatin exposure increases the ultrarapid delayed rectifier potassium current in mouse ventricular cardiomyocytes.
Although statins are among the most frequently prescribed drugs worldwide, their effect on the electrical activity of the heart, especially under chronic exposure, is poorly studied. We analyzed changes in the main repolarizing potassium currents in ventricular cardiomyocytes isolated from mice under chronic atorvastatin exposure. The mice received atorvastatin in drinking water at a dose of 10 mg/kg for 1 month. The whole-cell patch-clamp measurements showed an increase in the ultrarapid delayed rectifier potassium current I
Dzhumaniiazova et al. (2025) studied this question. Atorvastatin was evaluated on Ultrarapid delayed rectifier potassium current. Chronic atorvastatin exposure (10 mg/kg for 1 month) in mice led to an increase in the ultrarapid delayed rectifier potassium current in isolated ventricular cardiomyocytes.