What question did this study set out to answer?

To investigate the association of estimated whole blood viscosity with hemodynamic parameters and long-term prognosis in patients with heart failure with reduced ejection fraction.

January 23, 2019Biomarkers in Medicine

The Association of Estimated Whole Blood Viscosity with Hemodynamic Parameters and Prognosis in Patients with Heart Failure

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Why the study?

The association of estimated whole blood viscosity with hemodynamic parameters and prognosis in patients with heart failure with reduced ejection fraction had not been established.

Does estimated whole blood viscosity predict composite endpoints and mortality in patients with heart failure with reduced ejection fraction?

Population

542 patients with heart failure with reduced ejection fraction

Comparison

Estimated whole blood viscosity levels

Follow-up

Median 13 months

Authors

EÇElif Hande Özcan ÇetinElectrophysiology MÇMehmet Serkan ÇetinAnkara University KÇKumral ÇağlıSağlık Bilimleri Üniversitesi

Discussion

Member takes

Implication

WBV may refine HFrEF risk stratification; leaves open whether viscosity modulation alters outcomes.

Key Points

To investigate the association of estimated whole blood viscosity with hemodynamic parameters and long-term prognosis in patients with heart failure with reduced ejection fraction.
Enrolled 542 patients with heart failure with reduced ejection fraction.
Followed participants for a median duration of 13 months to assess clinical endpoints.
Evaluated high-shear and low-shear estimated whole blood viscosity in relation to right atrium pressure, cardiac index, composite endpoints, and all-cause mortality.
Whole blood viscosity parameters correlated negatively with right atrium pressure and positively with cardiac index.
Every 1 cP increase in high-shear and low-shear whole blood viscosity was associated with a 17% and 1% reduction in the composite endpoint, respectively.
Whole blood viscosity independently predicted all-cause mortality and composite endpoints, with Kaplan-Meier analysis confirming significantly worse outcomes in the lowest viscosity quartiles.

Structured PICO

Does estimated whole blood viscosity predict composite endpoints and mortality in patients with heart failure with reduced ejection fraction?

Population

542 patients with heart failure with reduced ejection fraction

Intervention

Estimated whole blood viscosity (WBV)

Comparator

Lower vs higher WBV quartiles

Outcome

Composite end point (CEP) and all-cause mortalitycomposite

Estimated whole blood viscosity is an independent predictor of composite endpoints and all-cause mortality in patients with HFrEF, with lower viscosity associated with worse outcomes.

Cite This Study

Çetin et al. (2019) studied this question.

synapsesocial.com/papers/6a02e07aa59fd503299e2260 https://doi.org/10.2217/bmm-2018-0309

Topics

Heart failure HFrEF treatment

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The Association of Estimated Whole Blood Viscosity with Hemodynamic Parameters and Prognosis in Patients with Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The Association of Estimated Whole Blood Viscosity with Hemodynamic Parameters and Prognosis in Patients with Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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