Key result
Supramedian values of whole blood viscosity were an independent predictor of left ventricular thrombus development, which occurred in 12.8% of patients within one year following acute anterior MI.
Why the study?
Despite treatment improvements for STEMI, left ventricular thrombus remains a concerning complication that may lead to systemic thromboembolism and stroke.
Does estimated whole blood viscosity predict left ventricular thrombus formation in patients surviving an acute anterior myocardial infarction?
Cohort (n=780)
Does estimated whole blood viscosity predict left ventricular thrombus formation in patients surviving an acute anterior myocardial infarction?
Estimated whole blood viscosity is an easily accessible parameter that independently predicts left ventricular thrombus formation within one year after acute anterior myocardial infarction.
Answers are grounded in this paper and cite their sources.
WBV may predict LV thrombus after anterior MI; hypothesis-generating, requiring prospective validation before any clinical use.
BACKGROUND: Despite improvements in treatment of ST-segment myocardial infarction (STEMI), thrombus formation in the left ventricle is still a concerning complication that may lead to systemic thromboembolism and stroke. OBJECTIVES: To evaluate the predictive value of estimated whole blood viscosity (WBV) for left ventricular thrombus development in patients surviving an acute anterior myocardial infarction (AAMI).MATERIALS \& METHODS:Seven hundred eighty AAMI patients who were treated percutaneously were enrolled consecutively. Serial echocardiographic examinations were performed within 24h of admission, before hospital discharge, and at 1, 3, 6 and 12 months following hospital discharge. WBV was calculated according to de Simones formula. RESULTS: One hundred patients (12.8%) developed thrombus formation within one year following AAMI. Patients with left ventricular thrombus (LVT) had significantly higher WBV values. Supramedian values of WBV at both low (0.5 sec-1) and high (208 sec-1) shear rates were found to be an independent predictor of LVT development. CONCLUSION: As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction.
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Çırakoğlu et al. (2020) conducted a cohort in Acute anterior myocardial infarction (n=780). Supramedian whole blood viscosity (WBV) vs. Inframedian whole blood viscosity was evaluated on Left ventricular thrombus formation within one year. Supramedian values of whole blood viscosity were an independent predictor of left ventricular thrombus development, which occurred in 12.8% of patients within one year following acute anterior MI.
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