Key result
Higher whole blood viscosity predicts ~141% greater odds of high thrombus burden in STEMI patients.
Why the study?
Increased whole blood viscosity is associated with adverse outcomes in STEMI, but its association with thrombus burden remained to be analyzed.
Does increased whole blood viscosity predict high thrombus burden in STEMI patients undergoing primary PCI?
Cross-Sectional (n=167)
Does increased whole blood viscosity predict high thrombus burden in STEMI patients undergoing primary PCI?
Effect estimate: OR 2.408 (HSR), OR 1.055 (LSR)
p-value: p=0.020 (HSR), 0.021 (LSR)
Increased whole blood viscosity is an independent predictor of high angiographic thrombus burden in patients with STEMI undergoing primary PCI.
May inform STEMI thrombus risk stratification; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: İncreased whole blood viscosity (WBV) is associated with increased infarct area, impaired microvascular circulation and mortality in patients with ST-elevation myocardial infarction (STEMI). OBJECTIVES: We aimed to analyze the association between the WBV and thrombus burden (TB) in STEMI patients. METHODS: This cross-sectional study included 167 STEMI patients who received primary percutaneous coronary intervention. WBV values were assessed using hematocrit and total protein values, and low shear rate(LSR) and high shear rate(HSR) were calculated. Angiographic TB was assessed according to the definition of the Thrombolysis in Myocardial Infarction (TIMI) study group. The cases were dichotomized into low TB (grade 1-3) (n = 87) and high TB (grade 4-5) (n = 80) groups. RESULTS: The mean HSR and LSR values of the high TB group were significantly increased compared to the low TB group (p < 0.001, for each). In ROC analysis,for prediction of TB, a cut-off value of 3.83 WBV for HSR had a 71% sensitivity and a 60.7% specificity, and a cut-off value of 21 WBV for LSR had a 70% sensitivity and 59.9% specificity (p < 0.001,for each). Multivariate regression analysis showed that both HSR (OR = 2.408;p=0.020) and LSR (OR = 1.055;p=0.021) were independent predictors for high TB. CONCLUSION: İncreased WBV was an independent predictor for the presence of high TB in patients with STEMI.
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Kaplangöray et al. (2023) conducted a cross-sectional in ST-segment elevation myocardial infarction (n=167). Whole blood viscosity (WBV) was evaluated on High thrombus burden (grade 4-5) (OR 2.408 (HSR), OR 1.055 (LSR), p=0.020 (HSR), 0.021 (LSR)). Increased whole blood viscosity at high and low shear rates independently predicted high thrombus burden in STEMI patients (HSR OR 2.408, p=0.020; LSR OR 1.055, p=0.021).
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