April 13, 2016Biomarkers in Medicine
Prognostic Significance of Whole Blood Viscosity Estimated by De Simone’s Formula in ST-Elevation Myocardial Infarction
Key result
Higher estimated whole blood viscosity (third tertile) was associated with an increased occurrence of in-hospital and long-term major adverse cardiovascular events over a median 34.6 months in STEMI.
Why the study?
Does estimated whole blood viscosity predict in-hospital and long-term MACE in patients with STEMI?
Population
1,835 patients with ST-elevation myocardial infarction (STEMI)
Comparison
Whole blood viscosity estimated by de Simone's… vs Lower WBV tertiles
Design
Cohort
Follow-up
median 34.6 months
Authors
Discussion
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Implication
May aid STEMI risk stratification; hypothesis-generating for viscosity-targeted interventions.
Study Design
Type
Cohort (n=1,835)
Structured PICO
Does estimated whole blood viscosity predict in-hospital and long-term MACE in patients with STEMI?
P
Population
1,835 patients with ST-elevation myocardial infarction (STEMI)
I
Intervention
Whole blood viscosity (WBV) estimated by de Simone's formula
C
Comparator
Lower WBV tertiles
O
Outcome
In-hospital and long-term major adverse cardiovascular events (MACE)composite
Estimated whole blood viscosity using de Simone's formula may serve as a feasible prognostic indicator for short- and long-term MACE in patients with STEMI.
Cite This Study
Çetin et al. (2016) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=1,835). Whole blood viscosity (WBV) estimated by De Simone's formula vs. Lower WBV tertiles was evaluated on In-hospital and long-term major adverse cardiovascular events (MACE). Higher estimated whole blood viscosity (third tertile) was associated with an increased occurrence of in-hospital and long-term major adverse cardiovascular events over a median 34.6 months in STEMI.