Key result
Long-term minoxidil administration in chronic left heart failure was associated with more total clinical events compared to placebo (21 vs 7 events; p<0.01), despite improving hemodynamics.
Why the study?
Does minoxidil improve hemodynamics and clinical outcomes in patients with chronic left heart failure?
Population
17 patients with chronic left heart failure
Comparison
Minoxidil added to digoxin and diuretics for 3… vs Placebo added to digoxin and diuretics for 3…
Design
RCT, random, double-blind
Follow-up
3 months
Authors
Loading...
Caution against long-term minoxidil in chronic HF despite hemodynamic improvement; challenges surrogate endpoints for clinical outcomes in heart failure.
RCT (n=17)
Double-blind
Random
Does minoxidil improve hemodynamics and clinical outcomes in patients with chronic left heart failure?
Absolute Event Rate: 233.3% vs 87.5%
p-value: p=<.01
Long-term minoxidil administration in chronic left heart failure improves hemodynamics and LVEF but is associated with a poorer clinical course and increased adverse events.
Franciosa et al. (1984) conducted an RCT in Chronic left heart failure (n=17). Minoxidil vs. Placebo was evaluated on Total clinical events (including increased need for diuretics, angina, ventricular arrhythmias, worsening heart failure, and death) (p=<.01). Long-term minoxidil administration in chronic left heart failure was associated with more total clinical events compared to placebo (21 vs 7 events; p<0.01), despite improving hemodynamics.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: