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January 14, 2022Reviews in Cardiovascular MedicineOpen Access

Sex beyond cardiovascular risk factors and clinical biomarkers of cardiovascular disease

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Key result

Sex differences in risk factors and biomarkers indicate distinct IHD mechanisms in women.

Why the study?

Traditional cardiovascular risk factors may interact differently with male and female coronary anatomy, and sex differences exist in prognostic inflammatory and necrosis biomarkers.

Design

Review

Authors

MBMaria BergamiUniversity of BolognaMSMarialuisa ScarponeUniversity of Bologna
Raffaele Bugiardini
Raffaele BugiardiniCross-Cutting Cardiology

Discussion

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Member takes

Overview

May inform sex-specific IHD risk assessment; leaves open prospective validation of tailored thresholds.

Structured PICO

P
Population
Men and women with or at risk of ischemic heart disease (IHD)

This review highlights significant sex-related differences in cardiovascular risk factors and biomarker expression, emphasizing the need for sex-specific risk stratification and thresholds in ischemic heart disease.

Limitations

  • Clinical and prognostic implications of sex differences in biomarkers are less extensively characterized.
  • Lack of clear and standardized sex-specific thresholds for indicators of inflammation, necrosis, and ventricular dysfunction.

Cite This Study

Bergami et al. (2022) conducted a review in Ischemic heart disease. Sex-related differences in cardiovascular risk factors and biomarkers such as C-reactive protein and troponins indicate that women have distinct pathophysiological mechanisms of ischemic heart disease.

synapsesocial.com/papers/6a05115efba2ba61ab55fae9https://doi.org/10.31083/j.rcm2301019
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Also Consider

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  1. 1Sex differences in ischemic heart disease and heart failure biomarkers2018 · 51 citations
  2. 2Sex-Specific Associations of Cardiovascular Risk Factors and Biomarkers With Incident Heart Failure2020 · 112 citations
  3. 3Sex Differences in Modifiable Risk Factors and Severity of Coronary Artery Disease2020 · 64 citations
  4. 4Sex Differences in Outcomes After STEMI2018 · 263 citations
  5. 5Gender differences in the association of C‐reactive protein with coronary artery calcium in Type‐2 diabetes2010 · 44 citations