Key result
High-dose loop diuretics induce greater diuresis than low doses in hospitalized HF patients.
Why the study?
Fluid retention is a major cause of symptoms and adverse outcomes in HF, yet loop diuretic therapy has remained largely unchanged for 50 years with few data guiding clinical practice.
What is the current evidence for different loop diuretic strategies in patients with heart failure?
What is the current evidence for different loop diuretic strategies in patients with heart failure?
Despite being the mainstay of congestion treatment in heart failure, loop diuretic strategies lack extensive data, though current evidence favors high-dose over low-dose therapy in hospitalized patients.
Supports higher-dose loop diuretics for decongestion in acute HF; leaves open whether guidelines should be updated.
PURPOSE OF REVIEW: Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion-loop diuretics-has remained largely unchanged for 50 years. In these two articles (part I: loop diuretics and part II: combination therapy), we will review the history of diuretic treatment and the current trial evidence for different diuretic strategies and explore potential future directions of research. RECENT FINDINGS: We will assess recent trials including DOSE, TRANSFORM, ADVOR, CLOROTIC, OSPREY-AHF, and PUSH-AHF amongst others, and assess how these may influence current practice and future research. There are few data on which to base diuretic therapy in clinical practice. The most robust evidence is for high dose loop diuretic treatment over low-dose treatment for patients admitted to hospital with HF, yet this is not reflected in guidelines. There is an urgent need for more and better research on different diuretic strategies in patients with HF.
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Cuthbert et al. (2024) conducted a review in Heart Failure. Loop Diuretics was evaluated. High-dose loop diuretic treatment induces greater diuresis than low-dose treatment for patients admitted to hospital with heart failure, though this robust evidence is not reflected in current guidelines.
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