Key result
Older age in habitually active adults was associated with lower peak SNA-MAP transduction (p<0.05) and a trend toward lower SNA-MCAv transduction (p=0.07) compared with younger adults.
Why the study?
It remained unclear whether sympathetic nerve activity dysregulation contributes to age-related impairments in cerebral hemodynamics, and whether these responses associate with VO2max.
Population
17 healthy young and 16 healthy older physically active adults
Comparison
Older adults (55-68 years) vs younger adults (20-35 years)
Design
Cross-sectional physiological study
Authors
Loading...
Lower sympathetic transduction may compromise cerebral perfusion during stress in older adults; leaves open its contribution to age-related cerebrovascular risk.
Cross-Sectional (n=33)
p-value: p=<0.05
Aging in habitually active adults is associated with reduced sympathetic transduction, suggesting that regular physical activity alone may not fully preserve resting sympathetic regulation of blood pressure and cerebral perfusion.
Liss-'s-Gravemade et al. (2026) conducted a cross-sectional in Healthy physically active adults (n=33). Older age vs. Younger age was evaluated on Peak SNA-MAP transduction (p=<0.05). Older age in habitually active adults was associated with lower peak SNA-MAP transduction (p<0.05) and a trend toward lower SNA-MCAv transduction (p=0.07) compared with younger adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: