August 1, 1997AJP Regulatory Integrative and Comparative Physiology
Influence of age on the sympathetic neural adjustments to alterations in systemic oxygen levels in humans
Key result
Aging does not influence MSNA or arterial blood pressure increases during acute hypoxemia or hyperoxemia.
- n=17
Why the study?
Do alterations in systemic O2 levels affect sympathetic nervous system activity and arterial blood pressure differently in young versus older healthy normotensive men?
Population
17 healthy normotensive men (10 young and 7 older)
Comparison
Moderate isocapnic hypoxemia and hyperoxemia vs Room air breathing (normoxic-control)
Design
Other
Authors
Discussion
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Implication
Supports similar sympathetic and BP responses to acute O2 changes across ages in healthy men; leaves open effects in cardiovascular disease.
Study Design
Type
Cross-Sectional (n=17)
Structured PICO
Do alterations in systemic O2 levels affect sympathetic nervous system activity and arterial blood pressure differently in young versus older healthy normotensive men?
P
Population
17 healthy normotensive men (10 young, 7 older) evaluated for sympathetic neural adjustments during moderate isocapnic hypoxemia and hyperoxemia.
I
Intervention
Moderate isocapnic hypoxemia (15 min of 10% fractional inspired O2) and hyperoxemia (10 min of 50% fractional inspired O2)
C
Comparator
Room air breathing (normoxic-control)
O
Outcome
Sympathetic nervous system activity to skeletal muscle (MSNA) and arterial blood pressuresurrogate
Aging does not significantly alter the absolute sympathetic neural or blood pressure responses to acute changes in systemic oxygen levels in healthy men, though baseline sympathetic activity is higher.
Cite This Study
Davy et al. (1997) conducted a cross-sectional in Healthy normotensive (n=17). Moderate isocapnic hypoxemia and hyperoxemia vs. Room air breathing (normoxic-control) was evaluated on Muscle sympathetic nerve activity (MSNA) and arterial blood pressure. Aging does not significantly influence the absolute increase in muscle sympathetic nerve activity or arterial blood pressure during acute hypoxemia or hyperoxemia in healthy men.