Haemodynamic Effects of an Acute Vasodilator Challenge in Heart Failure Patients with Reduced Ejection Fraction and Different forms of Post-Capillary Pulmonary Hypertension
Why the study?
Does acute vasodilator administration improve pulmonary haemodynamics differently based on the haemodynamic definition of post-capillary PH in HFrEF-PH patients?
Population
Heart failure patients with reduced ejection fraction and pulmonary hypertension (HFrEF-PH)
Comparison
Acute vasodilator administration vs Different haemodynamic definitions of…
Design
Cohort
Follow-up
acute
Authors
Discussion
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Implication
Comparable acute PVR reversibility across definitions suggests limited discriminatory value; leaves open optimal criteria for identifying vasodilator-responsive Cpc-PH in HFrEF.
Structured PICO
Does acute vasodilator administration improve pulmonary haemodynamics differently based on the haemodynamic definition of post-capillary PH in HFrEF-PH patients?
P
Population
Heart failure patients with reduced ejection fraction and pulmonary hypertension (HFrEF-PH)
I
Intervention
Acute vasodilator administration
C
Comparator
Different haemodynamic definitions of post-capillary PH (Cpc-PH, DPG ≥7 mmHg, TPG >12 mmHg)
O
Outcome
Reversibility of pulmonary hypertension (PVR, DPG, TPG)surrogate
Acute vasodilator administration improves PVR, DPG, and TPG in Cpc-PH patients, but persistent abnormalities in the PVR vs. PCa relationship remain.
Cite This Study
Ghio et al. (2017) studied this question.