Key result
Inflammatory cytokines are upregulated in experimental models of heart failure and may mediate non-lethal alteration of cardiac function and structural changes of the ventricle.
Population
Experimental models of cardiac diseases including murine model of myocarditis, pressure overloaded…
Design
Review
Authors
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Hypothesis-generating for anticytokine strategies in heart failure models; clinical translation and efficacy remain unproven.
This review highlights the pathophysiological role of inflammatory cytokines in the development and progression of heart failure across various experimental models, suggesting a potential target for immunomodulating therapies.
Shigetake Sasayama (1999) conducted a review in Heart failure. Immunomodulating or anticytokine therapy was evaluated. Inflammatory cytokines are upregulated in experimental models of heart failure and may mediate non-lethal alteration of cardiac function and structural changes of the ventricle.
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