Key result
Plasma levels of TNF-alpha significantly correlated with endothelium-dependent vasodilation following recompensation (r=0.750, P=0.001), but not during acute heart failure (r=0.098, P=0.719).
Why the study?
Does recompensation alter the relationship between pro-inflammatory cytokines and endothelium-dependent vasodilation in patients with congestive heart failure?
Population
16 patients with congestive heart failure during an episode of acute failure and at the time of recompensation
Comparison
Diuretic therapy to achieve recompensation vs Baseline (acute decompensated state)
Design
Cohort
Follow-up
11 +/- 3 days
Authors
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TNF-alpha–vasodilation correlation emerges only after HF recompensation; hypothesis-generating and should not yet alter acute management.
Observational (n=16)
Does recompensation alter the relationship between pro-inflammatory cytokines and endothelium-dependent vasodilation in patients with congestive heart failure?
p-value: p=0.001
In patients with congestive heart failure, plasma levels of pro-inflammatory cytokines correlate with endothelium-dependent vasodilation only following recompensation, suggesting acute decompensation masks this relationship.
Marc Vanderheyden (1998) conducted an observational in Congestive heart failure (n=16). Recompensation via diuretic therapy vs. Acute heart failure (decompensation) was evaluated on Correlation between TNF-alpha and percentage change in brachial artery diameter following reactive hyperaemia (p=0.001). Plasma levels of TNF-alpha significantly correlated with endothelium-dependent vasodilation following recompensation (r=0.750, P=0.001), but not during acute heart failure (r=0.098, P=0.719).
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