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May 15, 2026European journal of medical researchOpen Access

Urinary APOA1 may have greater potential for distinguishing colorectal cancer from colorectal polyps in men

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Authors

QMQian MengCapital Medical UniversityLWLupeng WangCapital Medical UniversityMHMei HuCapital Medical University

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Implication

Retrospective analysis identifies urinary APOA1 as a promising biomarker for distinguishing colorectal cancer from polyps in men, suggesting diagnostic potential.

Key Points

  • This study aims to identify urinary biomarkers for differentiating colorectal cancer from colorectal polyps in men.
  • Retrospective analysis of urine samples from male patients with colorectal cancer and colorectal polyps.
  • Utilized LC-MS/MS proteomics, Western blotting, and ELISA to analyze urinary protein expression.
  • Performed ROC curve analysis to evaluate the diagnostic performance of urinary APOA1.
  • Significantly higher urinary APOA1 levels were found in the colorectal cancer group (AUC values of 0.763 and 0.881).
  • Serum high-density lipoprotein levels showed the only significant difference between colorectal cancer and colorectal polyp patients.

Cite This Study

Meng et al. (2026) studied this question.

synapsesocial.com/papers/6a06b7eae7dec685947aa7b4https://doi.org/10.1186/s40001-026-04566-8
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