Key result
Obesity in ADHF shows no association with length of stay or 30-day outcomes.
Why the study?
Obesity is an independent risk factor for heart failure but paradoxically associated with a better prognosis, prompting evaluation of its relationship with acute decompensated heart failure outcomes.
Does obesity improve clinical outcomes in patients with acute decompensated heart failure?
Cohort (n=58)
No
Does obesity improve clinical outcomes in patients with acute decompensated heart failure?
Absolute Event Rate: 7.91% vs 6.65%
p-value: p=0.825
In a small prospective cohort of patients with acute decompensated heart failure, obesity was associated with numerically better but statistically non-significant clinical outcomes compared to non-obese patients.
No significant obesity effect on ADHF outcomes should not change practice; leaves open the obesity paradox for larger prospective validation.
Highlights: Clinical outcomes in obese acute decompensated heart failure patients were found to be better than those of non-obese patients but not statistically significant. Acute decompensated heart failure patients were dominated by males. Abstract Introduction: Obesity is an independent risk factor that raises the prevalence of heart failure, but it is paradoxically associated with a better prognosis. This study examined the relationship between obesity and clinical outcomes of acute decompensated heart failure at Dr. Soetomo General Academic Hospital, Surabaya. Methods: This was an analytic observational study using a prospective cohort design. Patients with acute decompensated heart failure who were admitted to the inpatient care unit of Dr. Soetomo General Academic Hospital, Surabaya, from December 2021 to July 2022 were chosen using a purposive sample technique. The data were analyzed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26.0. Results: There were 58 patients (n=58) representing different categories, with an average age of 55 years old, and were predominately males (58.6%). This study found that clinical outcomes in obese acute decompensated heart failure patients were better than those of non-obese patients in terms of shorter lengths of stay (p=0.825), lower rates of rehospitalization (p=0.458), and lower rates of all-cause mortality (p=0.673). Conclusion: The difference between the clinical outcomes in obese acute decompensated heart failure patients and non-obese patients was not statistically significant.
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Nuvus et al. (2025) conducted a cohort in Acute decompensated heart failure (n=58). Obesity (BMI ≥ 25 kg/m2) vs. Normal BMI (18.5-24.99 kg/m2) was evaluated on Length of stay (days) (p=0.825). Obesity in patients with acute decompensated heart failure did not significantly affect length of stay, 30-day rehospitalization, or 30-day all-cause mortality compared to non-obese patients.
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