Why the study?
Does obesity improve the composite outcome of re-admission due to heart failure and all-cause death in non-elderly patients with acute decompensated heart failure?
Observational (n=155)
No
Does obesity improve the composite outcome of re-admission due to heart failure and all-cause death in non-elderly patients with acute decompensated heart failure?
Hazard Ratio: 0.5 (95% CI 0.26–0.95)
p-value: p=0.03
Non-elderly acute decompensated heart failure patients with obesity demonstrated better mid-term clinical outcomes compared to those without obesity, extending the obesity paradox to this younger demographic.
, n = 74). The primary composite outcome of this study was defined as re-admission due to HF and all-cause death.The primary composite outcome was less frequently observed in the obesity group as compared with the non-obesity group (Hazard ratio [HR] 0.50, 95% confidence interval [CI] 0.26-0.95, P = 0.03). Re-admission due to HF was significantly less in the obesity group than in the non-obesity group (HR 0.44, 95% CI 0.23-0.86, P = 0.02), whereas all-cause death was not significantly different between the groups (P = 0.44).The mid-term outcomes in non-elderly HF patients with obesity were better as compared with non-elderly HF patients without obesity, which supports obesity paradox in this specific population.
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Ito et al. (2018) conducted an observational in Acute decompensated heart failure (n=155). Obesity (BMI ≥ 25 kg/m2) vs. Non-obesity (BMI < 25 kg/m2) was evaluated on Composite of re-admission due to heart failure and all-cause death (HR 0.50, 95% CI 0.26-0.95, p=0.03).
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