Key result
Low pulmonary artery pulsatility index predicts death or HF hospitalization in patients with AF.
Why the study?
Pulmonary artery pulsatility index is a hemodynamic index of right ventricular function, but its clinical impact in patients with heart failure and concomitant atrial fibrillation required investigation.
Does the pulmonary artery pulsatility index (PAPi) predict the composite of all-cause death or heart failure hospitalization in patients with heart failure and concomitant atrial fibrillation?
Cohort
No
Does the pulmonary artery pulsatility index (PAPi) predict the composite of all-cause death or heart failure hospitalization in patients with heart failure and concomitant atrial fibrillation?
In patients with heart failure and atrial fibrillation, a low pulmonary artery pulsatility index (PAPi) is an independent predictor of adverse outcomes, suggesting its utility in risk stratification.
Answers are grounded in this paper and cite their sources.
May aid risk stratification in HF with AF; hypothesis-generating and requires prospective validation.
BACKGROUND: right heart catheterisation, is a hemodynamic index of the right ventricular function. We investigated the clinical impact of PAPi in patients with HF and concomitant AF. METHODS: This was a single-center, retrospective cohort study involving consecutive patients who underwent right heart catheterisation for HF between January 2016 and December 2018. Patients with acute decompensated phase of HF were excluded. The primary endpoint was a composite of all-cause death or hospitalisation due to HF. CONCLUSION: AF was associated with reduced PAPi levels in patients with HF. Low PAPi independently predicted the prognosis of patients with AF and HF. Measuring PAPi provides useful information for the management of patients with HF and concomitant AF.
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Ozaki et al. (2025) conducted a cohort in Heart failure and atrial fibrillation. Pulmonary artery pulsatility index (PAPi) was evaluated on Composite of all-cause death or hospitalisation due to HF (p== 0.026). Low pulmonary artery pulsatility index independently predicted the composite of all-cause death or hospitalisation due to heart failure in patients with concomitant atrial fibrillation.
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