Why the study?
Does adding irbesartan or ramipril to diuretics improve quality of life, exercise capacity, and cardiac function in patients with heart failure with a normal ejection fraction?
Does adding irbesartan or ramipril to diuretics improve quality of life, exercise capacity, and cardiac function in patients with heart failure with a normal ejection fraction?
In patients with HFpEF, adding irbesartan or ramipril to diuretics does not significantly improve quality of life or symptoms beyond the benefits of diuretics alone, despite marginal improvements in echocardiographic parameters and NT-proBNP.
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Diuretics alone match combination regimens for QoL gains in HFpEF; confirms no additive symptomatic benefit from irbesartan or ramipril.
Yip et al. (2008) studied this question.
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