Key result
Percutaneous transluminal mitral valvuloplasty normalized elevated baseline muscle sympathetic nerve activity (42.1 vs 26.1 bursts/min in controls, P<.05) in patients with mitral stenosis.
Why the study?
Does percutaneous transluminal mitral valvuloplasty normalize sympathetic nerve activity and baroreflex sensitivity in patients with mitral stenosis?
Population
10 patients with mitral stenosis (mean age 48+/-2 years) and 10 healthy volunteers (mean age 47+/-4 years)
Comparison
Percutaneous transluminal mitral valvuloplasty vs Healthy volunteers and pre-valvuloplasty state
Design
Cohort
Follow-up
≥ 6 months
Authors
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May support valvuloplasty for autonomic normalization in mitral stenosis; leaves open effects on outcomes in prospective trials.
Observational (n=20)
Does percutaneous transluminal mitral valvuloplasty normalize sympathetic nerve activity and baroreflex sensitivity in patients with mitral stenosis?
Absolute Event Rate: 42.1% vs 26.1%
p-value: p=<.05
Percutaneous transluminal mitral valvuloplasty normalizes the elevated sympathetic nerve activity and impaired baroreflex sensitivity seen in patients with mitral stenosis.
Ashino et al. (1997) conducted an observational in Mitral stenosis (n=20). Percutaneous Transluminal Mitral Valvuloplasty vs. Healthy volunteers and baseline was evaluated on Muscle sympathetic nerve activity at baseline (bursts/min) (p=<.05). Percutaneous transluminal mitral valvuloplasty normalized elevated baseline muscle sympathetic nerve activity (42.1 vs 26.1 bursts/min in controls, P<.05) in patients with mitral stenosis.
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