Key result
Isoproterenol infusion shortened ventricular monophasic action potentials by 12-18 msec, with early nonhomogeneous and late homogeneous shortening producing opposite effects on T wave polarity.
Regional differences in monophasic action potential shortening induced by isoproterenol explain the high sensitivity and low specificity of primary T wave abnormalities.
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May explain T-wave changes during sympathetic activation; leaves open translation to human ECG interpretation.
Autenrieth et al. (1975) studied Primary T wave abnormalities. Isoproterenol (ISP) was evaluated on Primary T wave changes and changes of monophasic action potentials (MAP). Isoproterenol infusion shortened ventricular monophasic action potentials by 12-18 msec, with early nonhomogeneous and late homogeneous shortening producing opposite effects on T wave polarity.
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