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May 16, 2026Journal of Experimental PharmacologyOpen Access

Sub-Acute Toxicity Evaluation and Antiurolithiatic Activity of Tribulus terrestris Ethanol Extract in Rats

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Authors

AAAhmed Al-MohamadiUniversity of Science and TechnologyIEImadeldin M Taj EldinAl-Razi UniversityDIDoa’a IbrahimUniversity of Science and Technology

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Implication

Randomized trial evaluates the safety and antiurolithiatic effects of Tribulus terrestris in rats, suggesting its potential therapeutic use.

Key Points

  • This study evaluates the sub-acute toxicity and antiurolithiatic activity of ethanol extract of Tribulus terrestris.
  • Assess sub-acute toxicity in Wistar rats (n=30) over 28 days with EETT at doses of 500 and 1000 mg/kg.
  • Evaluate antiurolithiatic activity using nephrolithiasis model (n=36) with EETT at 150, 300, and 450 mg/kg.
  • Analyze hematological, biochemical, and histopathological parameters.
  • EETT showed no mortality or treatment-related toxicity, with stable body and organ weights.
  • EETT significantly reduced serum creatinine, urea, calcium, and potassium levels (P<0.05).
  • Histopathological examination indicated reduced calcium oxalate crystal deposits and preserved renal architecture.

Cite This Study

Al-Mohamadi et al. (2026) studied this question.

synapsesocial.com/papers/6a080b4ea487c87a6a40d874https://doi.org/10.2147/jep.s609388
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