Key result
CAD is associated with ~19% greater EAT thickness versus asymptomatic controls.
Why the study?
Is Epicardial Adipose Tissue (EAT) thickness associated with coronary artery disease, age, and gender?
Case-Control (n=315)
Is Epicardial Adipose Tissue (EAT) thickness associated with coronary artery disease, age, and gender?
Absolute Event Rate: 16.77% vs 14.13%
p-value: p=0.02
Epicardial adipose tissue thickness measured by echocardiography is significantly higher in patients with coronary artery disease and increases with age, suggesting its potential utility as an imaging marker for cardiovascular risk.
May support EAT thickness as an echocardiographic CAD marker; case-control data leave causal inference and practice change open.
Objectives: The aim of this study was to measure the Epicardial Adipose Tissue thickness through echocardiography in healthy adults and coronary artery disease patients and to make its association with age and gender. Methods: It was a case control study. A total of 315 samples including 159 cases of coronary artery disease and 156 asymptomatic individuals for coronary artery disease underwent echocardiography for Epicardial Adipose Tissue thickness measurement. Results: Mean Epicardial Adipose Tissue (EAT) in the study was found to be 15.45 ± 7.16 mm. Cases had significantly higher EAT 16.77 ±9.80mm as compared to controls 14.13 ± 4.52 mm (P=0.02). EAT thickness increased significantly with age (P=0.004). There was no significant difference of EAT (P=0.999) in both the genders. Conclusion: The mean EAT thickness is significantly higher in our study population as compared to previous studies. The mean EAT thickness was same in both males and females of our study. There was no significant difference in EAT of both genders.
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Shaheen et al. (2018) conducted a case-control in Coronary artery disease (n=315). Epicardial Adipose Tissue (EAT) thickness measurement vs. Asymptomatic individuals (healthy controls) was evaluated on Epicardial Adipose Tissue (EAT) thickness in mm (p=0.02). Epicardial Adipose Tissue (EAT) thickness was significantly higher in patients with coronary artery disease (16.77 ± 9.80 mm) compared to asymptomatic controls (14.13 ± 4.52 mm; P=0.02).
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