What question did this study set out to answer?

This study examines how diabetes and hypertension affect left ventricular diastolic filling.

April 1, 1995American Journal of Hypertension

Left Ventricular Diastolic Filling in Diabetes Mellitus With and Without Hypertension

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Why the study?

Does diabetes mellitus with or without hypertension alter left ventricular diastolic filling in patients without clinical heart disease compared to healthy controls?

Population

168 subjects: 84 diabetic patients without evidence of heart disease and 84 normotensive nondiabetic age…

Comparison

Diabetes mellitus with or without arterial… vs Normotensive nondiabetic age- and sex-matched…

Design

Cross-sectional

Authors

ANAntonio NicolinoUniversity of Sannio

Discussion

Member takes

Implication

May warrant diastolic screening in asymptomatic diabetics; leaves open whether BP control alters progression.

Key Points

This study examines how diabetes and hypertension affect left ventricular diastolic filling.
Examined 84 diabetic patients and 84 matched controls using Doppler echocardiography.
Patients divided into normotensive and hypertensive groups based on blood pressure status.
Measured various Doppler indices to assess diastolic filling and dysfunction.
Increased peak atrial flow velocity and atrial filling fraction observed in diabetic groups compared to controls.
Diastolic dysfunction evident in 32% of normotensive and 40% of hypertensive diabetics.
Hypertensive patients showed greater impairment in diastolic filling indices.

Structured PICO

Does diabetes mellitus with or without hypertension alter left ventricular diastolic filling in patients without clinical heart disease compared to healthy controls?

Population

168 subjects: 84 diabetic patients without evidence of heart disease (41 normotensive, mean age 63.7, 19 men/22 women; 43 hypertensive, mean age 65.6, 15 men/28 women) and 84 normotensive nondiabetic age- and sex-matched control subjects.

Intervention

Diabetes mellitus with or without arterial hypertension

Comparator

Normotensive nondiabetic age- and sex-matched control subjects

Outcome

Left ventricular diastolic filling measured by Doppler echocardiography (including peak atrial flow velocity, velocity integral for the atrial filling period, atrial filling fraction, ratio of peak early to peak atrial flow velocity, and ratio of flow velocity integrals)surrogate

Diastolic filling is frequently altered in diabetic patients without clinical heart disease, and coexisting hypertension further impairs left ventricular relaxation.

Cite This Study

Antonio Nicolino (1995) studied this question.

synapsesocial.com/papers/6a082f12280cd4e998e8acd2 https://doi.org/10.1016/0895-7061(95)00022-h

Topics

Hypertension management Echocardiography

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Left Ventricular Diastolic Filling in Diabetes Mellitus With and Without Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Left Ventricular Diastolic Filling in Diabetes Mellitus With and Without Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider