Why the study?
Animal models of diabetic cardiomyopathy fail to recapitulate key human factors like long-term insulin resistance, therapeutic intervention, and advanced age, creating caveats when extrapolating preclinical findings to clinical reality.
Future preclinical studies of diabetic cardiomyopathy must integrate key confounding factors such as age, disease duration, and therapeutic interventions to better mimic the human phenotype.
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Rodent diabetic cardiomyopathy models limit clinical translation; leaves open improved preclinical designs incorporating age, duration, and therapies.
Lezoualc’h et al. (2022) studied this question.
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