Key result
Rodent models of diabetic cardiomyopathy show early diastolic dysfunction and fibrosis but rarely develop HFrEF.
Why the study?
Diabetic cardiomyopathy prevalence has increased, but its pathogenesis is not fully understood, consensus on therapies is lacking, and experimental rodent models require description and quantitative comparison.
Meta-Analysis (n=651)
Rodent models of diabetic cardiomyopathy primarily mimic early-stage disease with diastolic dysfunction and hypertrophy, but rarely progress to symptomatic HFrEF as seen in humans.
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Caution extrapolating rodent diabetic cardiomyopathy data to human HFrEF; confirms models' limited progression and need for refined preclinical systems.
Magdalena Jasińska-Stroschein (2023) conducted a meta-analysis in Diabetic cardiomyopathy (n=651). Preclinical rodent models was evaluated on Presentation of diabetic cardiomyopathy (hemodynamic, echocardiographic, histopathologic and metabolic parameters). Preclinical rodent models of diabetic cardiomyopathy predominantly display early-stage features like diastolic dysfunction and myocardial fibrosis, but rarely progress to symptomatic HFrEF.
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