Key result
Experimental animal models of diabetic cardiomyopathy, ranging from transgenic rodents to large mammals, offer distinct advantages and limitations for basic and translational cardiovascular research.
Why the study?
Current diabetic cardiomyopathy research relies heavily on transgenic rodent models with debated clinical relevance, often overlooking spontaneously occurring diabetes in larger mammals, highlighting the need to evaluate popular animal models to guide translational research.
This review provides a comprehensive overview of experimental animal models for diabetic cardiomyopathy to guide future translational research.
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Animal model limitations in diabetic cardiomyopathy research leave open translational questions; human studies needed.
Richter et al. (2021) conducted a review in Diabetic Cardiomyopathy. Experimental animal models was evaluated. Experimental animal models of diabetic cardiomyopathy, ranging from transgenic rodents to large mammals, offer distinct advantages and limitations for basic and translational cardiovascular research.
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