Key result
Blood pressure lowering across all major antihypertensive classes reduces stroke and major cardiovascular events.
Why the study?
Does blood pressure lowering by major antihypertensive drug classes reduce cardiovascular outcomes in individuals with hypertension?
Meta-Analysis (n=195,267)
Does blood pressure lowering by major antihypertensive drug classes reduce cardiovascular outcomes in individuals with hypertension?
Blood pressure lowering by any major antihypertensive drug class significantly reduces stroke and major cardiovascular events, supporting the concept that risk reduction is primarily due to BP lowering per se.
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Prioritizes achieving blood pressure targets over specific drug selection for cardiovascular protection; confirms.
Thomopoulos et al. (2014) conducted a meta-analysis in hypertension (n=195,267). Antihypertensive drugs vs. Placebo or no treatment was evaluated on Seven fatal and nonfatal cardiovascular outcomes. Blood pressure lowering by all major antihypertensive drug classes (achieving SBP/DBP reductions of -10.5/-7 to -12/-5 mmHg) significantly reduced stroke and major cardiovascular events.
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