September 25, 2014Journal of Hypertension
Effects of blood pressure lowering on outcome incidence in hypertension
Why the study?
Does blood pressure-lowering treatment reduce fatal and nonfatal outcomes in all grades of hypertension, and what are the optimal target BP levels?
Population
Up to 128,232 individuals from up to 68 RCTs with hypertension, including those with grade 1 hypertension at…
Comparison
Blood pressure-lowering treatment vs Control or less intensive blood pressure lowering
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
Supports BP-lowering in low-risk grade 1 hypertension; extends evidence across all grades with <140/90 mmHg targets.
Structured PICO
Does blood pressure-lowering treatment reduce fatal and nonfatal outcomes in all grades of hypertension, and what are the optimal target BP levels?
P
Population
Up to 128,232 individuals from up to 68 RCTs with hypertension (grades 1, 2, and 3), including those with grade 1 hypertension at low-to-moderate risk.
I
Intervention
Blood pressure-lowering treatment
C
Comparator
Control or less intensive blood pressure lowering
O
Outcome
Seven fatal and nonfatal outcomes (including stroke, coronary events, and all-cause death)hard clinical
Blood pressure-lowering treatment is beneficial across all hypertension grades, including grade 1 at low-to-moderate risk, with optimal targets of <140/90 mmHg, while <130/80 mmHg provides additional stroke reduction.
Cite This Study
Thomopoulos et al. (2014) studied this question.