Key result
Renal denervation improves LVEF and attenuates myocardial fibrosis in male rats with post-MI heart failure.
Why the study?
Does renal denervation improve ventricular sympathetic nerve innervation and function in male rats with post-MI heart failure?
Does renal denervation improve ventricular sympathetic nerve innervation and function in male rats with post-MI heart failure?
p-value: p=< 0.05
Renal denervation improves cardiac sympathetic innervation and function in a rat model of post-MI heart failure.
May improve LV function in post-MI HF models; extends preclinical sympathetic data but leaves human translation open.
< 0.05) and tissue norepinephrine content. MI was associated with an increase in fibrosis of the noninfarcted ventricular myocardium, which was attenuated by RDx. RDx improved LV ejection fraction and end-systolic and -diastolic areas when compared with pre-RDx levels. This is the first study to show an interaction between renal nerve activity and cardiac sympathetic nerve innervation in heart failure. Our findings show denervating the renal nerves improves cardiac sympathetic innervation and function in the post-MI failing heart.
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Pinkham et al. (2017) studied Heart failure post-myocardial infarction. Renal denervation (RDx) vs. Pre-RDx levels / MI without RDx was evaluated on Ventricular sympathetic nerve innervation, function, and fibrosis (p=< 0.05). Renal denervation in male rats with post-myocardial infarction heart failure attenuated myocardial fibrosis and improved left ventricular ejection fraction and cardiac sympathetic innervation.
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