Key result
Elevated lipoprotein(a) is an emerging risk factor that increases the risk of developing heart failure and correlates with a poorer prognosis and higher incidence of adverse cardiovascular events.
Why the study?
The causal role of lipoprotein(a) in heart failure has not been clearly defined, and results regarding the influence of elevated lipoprotein(a) on HF development and course remain uncertain.
Elevated Lipoprotein(a) is emerging as a novel risk factor for heart failure development and a prognostic biomarker, though the efficacy of Lp(a)-lowering therapies in HF populations requires further dedicated trials.
Heart failure (HF) is one of the most difficult challenges in cardiology nowadays, constituting a significant global epidemiological, social and economic burden. For many years, there has been a search for new risk factors that predispose to the development of HF and biomarkers that could indicate HF patients with a poorer prognosis. Lipoprotein(a) (Lp[a]) is an estimated risk factor for atherosclerotic cardiovascular disease and aortic valve stenosis, but its causal role in HF has not been clearly defined yet. The results of the few studies regarding the influence of elevated Lp(a) on the development and course of HF are uncertain. However, most authors suggest that elevated Lp(a) increases the risk of HF and may correlate with a higher risk of major adverse cardiovascular events. The aim of this review is to present the current state of knowledge on the importance of the association between Lp(a) levels and HF, from pathophysiology to clinical practice including current management.
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Kowalczys et al. (2026) conducted a review in Heart failure. Elevated Lipoprotein(a) vs. Normal or lower Lipoprotein(a) levels was evaluated. Elevated lipoprotein(a) is an emerging risk factor that increases the risk of developing heart failure and correlates with a poorer prognosis and higher incidence of adverse cardiovascular events.
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