Key result
Cardiorespiratory fitness mediates ~31% of the link between physical comorbidity and depression in cancer survivors.
Why the study?
The study was conducted to determine the relationship between physical comorbidity and depression in Korean adult cancer survivors, and to assess whether non-exercise estimated cardiorespiratory fitness mediates this relationship.
Does estimated cardiorespiratory fitness mediate the relationship between physical comorbidity and depression in adult cancer survivors?
Cross-Sectional (n=448)
Does estimated cardiorespiratory fitness mediate the relationship between physical comorbidity and depression in adult cancer survivors?
Estimated cardiorespiratory fitness partially mediates the relationship between physical comorbidities and depression in cancer survivors, suggesting that improving fitness may mitigate depression risk.
Answers are grounded in this paper and cite their sources.
eCRF may mediate comorbidity-depression links in cancer survivors; hypothesis-generating, needs longitudinal trials before practice change.
To determine relationship between physical comorbidity (PC) and depression in Korean adults’ cancer survivors and understand if non-exercise estimation of cardiorespiratory fitness (eCRF) might have a mediating effect on such relationship. Data of 448 cancer survivors aged 20–64 years old in Korean National Health and Nutrition Examination Survey Ⅶ-Ⅷ (2016–2020) were analyzed. Depression was assessed with a 9-item Patient Health Questionnaire (PHQ-9). Subjects were categorized into two groups: normal and depression. PC was defined if a participant was diagnosed by a physician or was being treated at the time of the survey. eCRF was determined with sex and age-specific algorithms. In the mediation model, PC (β = 1.836, 95%CI: 1.577 to 2.095, p < 0.001) was significantly association with depression and eCRF levels mediated (indirect effect = 0.094, bootstrap 95%CI: 0.028 to 0.146) this association. Mediation analysis showed a significant, direct, and indirect effect with a significant Sobel test value (z = 2.517, p = 0.011). The relationship between PC and depression was significantly mediated by eCRF levels. Early physical activity interventions might prevent depression in cancer survivors with chronic diseases.
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Jin et al. (2023) conducted a cross-sectional in Depression in cancer survivors with physical comorbidity (n=448). Estimated cardiorespiratory fitness (eCRF) was evaluated on Mediating effect of eCRF on the association between physical comorbidity and depression (Indirect effect 0.094, 95% CI 0.028-0.146, p=0.011). Estimated cardiorespiratory fitness significantly mediated the relationship between physical comorbidity and depression in Korean adult cancer survivors, accounting for 30.6% of the total effect.
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