Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons
Why the study?
Are higher serum resistin concentrations associated with an increased risk of incident heart failure in older persons?
Population
2902 older persons without prevalent HF enrolled in the Health, Aging, and Body Composition Study.
Design
Cohort
Follow-up
median 9.4 years
Authors
Discussion
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Member takes
Implication
Resistin may help stratify HF risk in older adults; leaves open causal role and clinical utility pending prospective validation.
Structured PICO
Are higher serum resistin concentrations associated with an increased risk of incident heart failure in older persons?
P
Population
2902 older persons without prevalent HF (age, 73.6+/-2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study.
I
Intervention
Baseline serum resistin concentrations
O
Outcome
Incident heart failurehard clinical
Higher baseline serum resistin concentrations are independently associated with an increased risk of developing new-onset heart failure in older adults.
Cite This Study
Butler et al. (2009) studied this question.