Key result
A 10 beats per minute increase in resting heart rate was independently associated with increased cardiovascular (HR 1.14; 95% CI 1.07-1.22) and all-cause mortality (HR 1.09; 95% CI 1.05-1.14).
Why the study?
Is elevated resting heart rate independently associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers in a healthy general population?
Population
6,518 healthy subjects from the Danish general population
Comparison
Elevated resting heart rate vs Lower resting heart rate
Design
Cohort
Follow-up
18 years
Authors
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Supports resting heart rate as independent prognostic marker; extends prior associations by adjustment for inflammation but requires prospective validation.
Cohort (n=6,518)
Is elevated resting heart rate independently associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers in a healthy general population?
Effect estimate: HR 1.14 (CV) and HR 1.09 (all-cause) (95% CI 1.07-1.22 (CV) and 1.05-1.14 (all-cause))
Resting heart rate is an independent risk factor for cardiovascular and all-cause mortality, and not merely a marker of chronic low-grade inflammation.
Jensen et al. (2011) conducted a cohort in Healthy subjects (n=6,518). Resting heart rate was evaluated on Cardiovascular and all-cause mortality (HR 1.14 (CV) and HR 1.09 (all-cause), 95% CI 1.07-1.22 (CV) and 1.05-1.14 (all-cause)). A 10 beats per minute increase in resting heart rate was independently associated with increased cardiovascular (HR 1.14; 95% CI 1.07-1.22) and all-cause mortality (HR 1.09; 95% CI 1.05-1.14).
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