Key result
Higher resting heart rate (highest vs. lowest third) was associated with increased risk of incident heart failure hospitalization (HR 1.78; 95% CI 1.21-2.63; P=0.003) and cardiovascular mortality.
Why the study?
Does higher resting heart rate increase the risk of incident heart failure and cardiovascular mortality in older adults with cardiovascular risk factors?
Population
4084 older adults aged 70-82 years with known cardiovascular risk factors or previous cardiovascular…
Comparison
Highest distribution third of resting heart rate vs Lowest distribution third of resting heart rate
Design
Cohort
Follow-up
3.2-year
Authors
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Higher resting heart rate may identify higher-risk older adults; leaves open whether lowering it improves outcomes.
Cohort (n=4,084)
Does higher resting heart rate increase the risk of incident heart failure and cardiovascular mortality in older adults with cardiovascular risk factors?
Hazard Ratio: 1.78 (95% CI 1.21–2.63)
p-value: p=0.003
Increased resting heart rate is associated with higher risks of incident heart failure and cardiovascular mortality in older adults, which is only partially explained by systemic inflammation and endothelial dysfunction.
Nanchen et al. (2012) conducted a cohort in Cardiovascular risk factors or previous cardiovascular disease (n=4,084). Resting heart rate vs. Lowest distribution third was evaluated on Incident HF hospitalization (HR 1.78, 95% CI 1.21-2.63, p=0.003). Higher resting heart rate (highest vs. lowest third) was associated with increased risk of incident heart failure hospitalization (HR 1.78; 95% CI 1.21-2.63; P=0.003) and cardiovascular mortality.
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