Key result
The highest quartile of inflammation combined with a resting heart rate ≥75 b.p.m. strongly increased cardiovascular mortality risk (HR 7.50; 95% CI 3.21-17.50; P<0.0001).
Why the study?
Does elevated resting heart rate amplify the risk of cardiovascular mortality associated with inflammation in patients undergoing coronary angiography?
Cohort (n=3,267)
Does elevated resting heart rate amplify the risk of cardiovascular mortality associated with inflammation in patients undergoing coronary angiography?
Hazard Ratio: 7.5 (95% CI 3.21–17.5)
p-value: p=< 0.0001
Elevated resting heart rate strongly amplifies the cardiovascular mortality risk associated with systemic inflammation in patients undergoing coronary angiography.
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Elevated heart rate plus inflammation may signal higher CV mortality risk in angiography patients; leaves open whether joint targeting improves outcomes.
Hartaigh et al. (2012) conducted a cohort in scheduled for coronary angiography (n=3,267). Highest quartile of inflammation and resting heart rate ≥75 b.p.m. vs. Reference group was evaluated on cardiovascular mortality (HR 7.50, 95% CI 3.21-17.50, p=< 0.0001). The highest quartile of inflammation combined with a resting heart rate ≥75 b.p.m. strongly increased cardiovascular mortality risk (HR 7.50; 95% CI 3.21-17.50; P<0.0001).
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