Key result
Atrial cardiomyopathy and LA mechanical dysfunction emerge as proposed key drivers of the HFpEF phenotype.
This review highlights atrial cardiomyopathy as a critical pathophysiological mechanism and risk factor for the development of heart failure with preserved ejection fraction, particularly in the context of atrial fibrillation.
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May implicate atrial cardiomyopathy in HFpEF; hypothesis-generating and requires prospective validation before practice change.
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Jorge et al. (2022) conducted a review in Heart failure with preserved ejection fraction (HFpEF) and atrial cardiomyopathy. Atrial cardiomyopathy and mechanical dysfunction of the left atrium are proposed as key generators of the unique clinical phenotype of heart failure with preserved ejection fraction.
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