Key result
Nicorandil suppresses ischemia-induced ventricular tachyarrhythmias and AF by improving electrical remodeling via KATP channels.
Why the study?
Does nicorandil prevent ischemia-induced cardiac tachyarrhythmias in preclinical canine models?
Does nicorandil prevent ischemia-induced cardiac tachyarrhythmias in preclinical canine models?
Activation of KATP channels with nicorandil protects against ischemia-induced atrial and ventricular tachyarrhythmias by modulating cardiac electrical remodeling.
Hypothesis-generating in canine ischemia models; leaves open clinical translation for arrhythmia prevention.
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Matsushita et al. (2015) conducted a review in Ischemia-induced cardiac tachyarrhythmia. Nicorandil (KATP channel opener) was evaluated on Ischemia-induced tachyarrhythmia and atrial fibrillation. Nicorandil suppressed ischemia-induced ventricular tachyarrhythmias and atrial fibrillation by improving electrical remodeling via mitochondrial and sarcolemmal KATP channels.
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