Influence of receptor selectivity on benefits from SGLT2 inhibitors in patients with heart failure: a systematic review and head-to-head comparative efficacy network meta-analysis

Figures

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  Fig. 1. L’Abbé-plot of trials investigating the effects of SGLT2i on the composite outcome of hospitalizations for HF or CV death. CV cardiovascular, HF heart failure. The l’Abbé-plot plots the event rate in the experimental (intervention) group against the event rate in the control group. Trials in which the experimental treatment proves better than the control will be in the upper left of the plot, between the y axis and the line of equality. If experimental treatment is no better than control then the point will fall on the line of equality, and if control is better than experimental then the point will be in the lower right of the plot, between the x axis and the line of equality. The symbol size represents the sample size of the respective trials

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  Fig. 2. Predictive interval plot of individual SGLT2i for the combined primary endpoint of hospitalization for HF or CV death. CV cardiovascular, HF heart failure, SGLT2i sodium-glucose cotransporter 2 inhibitor. The predictive interval plot represents a forest plot of the joint estimated summary effects from both direct and indirect comparisons along with their confidence intervals. Significant summary effects are shown in red

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  Fig. 3. Graphical ranking of SGLT2i based on SUCRA values (hospitalization for HF or CV death). CANA canagliflozin, CV cardiovascular, DAPA dapagliflozin, EMPA empagliflozin, ERTU ertugliflozin, HF heart failure, PLA placebo, SITA sitagliptin, SOTA sotagliflozin

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  Fig. 4. Predictive interval plot of selective vs. non-selective SGLT2i for the combined primary endpoint of hospitalization for HF or CV death. CV cardiovascular, HF heart failure, SGLT2i sodium-glucose cotransporter 2 inhibitor. The predictive interval plot represents a forest plot of the joint estimated summary effects from both direct and indirect comparisons along with their confidence intervals. Significant summary effects are shown in red

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  Fig. 5. Relationship between effect size and receptor selectivity of SGLT2i for the combined primary endpoint of hospitalizations for HF or CV death. CI confidence interval, CV cardiovascular, ES effect size, HF heart failure, SGLT2i sodium-glucose cotransporter 2 inhibitor. Each bubble represents an SGLT2i trial. The symbol size represents the sample size of the respective trials