Key result
Atrial fibrillation and heart failure share complex hemodynamic, neuro-hormonal, inflammatory, and electrophysiologic mechanisms that mutually accelerate progression and increase mortality.
This review summarizes the complex pathophysiological relationship between atrial fibrillation and heart failure and provides updates on managing this dual epidemic.
Supports integrated AF-HF vigilance in practice; leaves open mechanism-targeted trials to slow mutual progression.
Atrial fibrillation (AF) and heart failure (HF) have emerged as major cardiovascular epidemics in developed nations over the past decade. They share similar risk factors, seem to mutually accelerate progression and are associated with increased morbidity and mortality. Their relationship involves complex hemodynamic, neuro-hormonal, inflammatory and electrophysiologic mechanisms, which go beyond just mutual risk factors. This review focuses on updates in AF and HF with a hope of better understanding this relationship and the management of this complex duo.
No takes yet. Share an insight, caveat, or question.
Sharma et al. (2013) conducted a review in Atrial fibrillation and heart failure. Atrial fibrillation and heart failure share complex hemodynamic, neuro-hormonal, inflammatory, and electrophysiologic mechanisms that mutually accelerate progression and increase mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: