Key result
Comorbid AF during HF hospitalizations is linked to ~38% higher in-hospital mortality.
Why the study?
Heart failure and atrial fibrillation frequently coexist and may worsen outcomes, but limited contemporary evidence describes their combined prevalence across HFpEF and HFrEF hospitalizations in the United States.
What are the national trends in the prevalence, outcomes, and costs of atrial fibrillation during hospital admissions for heart failure?
Population
10 392 189 hospitalizations for HF in the United States between 2008 and 2017
Comparison
Comorbid AF vs without AF in HF hospitalizations
Design
Retrospective database study using the National Inpatient Sample
Authors
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Comorbid AF flags higher mortality risk in HF admissions; leaves open whether targeted interventions improve outcomes.
Observational (n=10,392,189)
Yes
What are the national trends in the prevalence, outcomes, and costs of atrial fibrillation during hospital admissions for heart failure?
Absolute Event Rate: 3.6% vs 2.6%
p-value: p=<0.001
Atrial fibrillation is increasingly common among heart failure hospitalizations and is associated with higher in-hospital mortality and costs.
Reinhardt et al. (2021) conducted an observational in Heart failure (n=10,392,189). Comorbid atrial fibrillation vs. No atrial fibrillation was evaluated on In-hospital mortality (p=<0.001). Comorbid atrial fibrillation during heart failure hospitalizations was associated with higher in-hospital mortality compared to those without atrial fibrillation (3.6% vs 2.6%; P<0.001).
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