Key result
The AC/CC genotype of the angiotensin II type 1 receptor was associated with significantly higher phenylephrine-induced contractions in human mammary arteries than the AA genotype (1.47 vs 1.22 mN/mg, p<0.001).
Why the study?
Does the Angiotensin II type 1 receptor gene polymorphism (AC/CC vs AA) alter vascular reactivity in human mammary arteries in vitro?
Observational (n=50)
Does the Angiotensin II type 1 receptor gene polymorphism (AC/CC vs AA) alter vascular reactivity in human mammary arteries in vitro?
Absolute Event Rate: 1.47% vs 1.22%
p-value: p=<0.001
The Angiotensin II type 1 receptor A1166C gene polymorphism is associated with increased baseline vascular reactivity to phenylephrine but reduced potentiation by Angiotensin II in human mammary arteries in vitro.
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Hypothesis-generating for AT1R polymorphism effects on vascular tone; leaves open clinical relevance in human arteries.
Henrion et al. (1998) conducted an observational in Coronary artery disease (n=50). AC/CC genotype (A1166C polymorphism) vs. AA genotype was evaluated on Maximum phenylephrine-induced contraction response (p=<0.001). The AC/CC genotype of the angiotensin II type 1 receptor was associated with significantly higher phenylephrine-induced contractions in human mammary arteries than the AA genotype (1.47 vs 1.22 mN/mg, p<0.001).
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