Key result
Hypertrophic cardiomyopathy presents with symptoms like exertional angina and dyspnea, which do not always correlate directly with a single pathophysiologic mechanism or the magnitude of hypertrophy.
This review highlights that while symptom severity in hypertrophic cardiomyopathy generally correlates with left ventricular hypertrophy magnitude, exceptions exist.
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Symptoms in hypertrophic cardiomyopathy require assessment beyond hypertrophy magnitude; challenges direct correlation assumptions and leaves open mechanism-specific research.
(Second of Two Parts)Interrelation between Pathophysiologic Mechanisms and Disease ManifestationsSymptomsThe chief symptoms of hypertrophic cardiomyopathy are exertional angina, dyspnea, fatigue, and impaired consciousness (transient spells of lightheadedness, near-syncope, and syncope). However, a direct, one-to-one correlation between a particular symptom and a single pathophysiologic mechanism does not always exist. For example, in a population of patients with hypertrophic cardiomyopathy, a general relation exists between the severity of symptoms and the magnitude of left ventricular hypertrophy19; however, this correlation is not absolute, and some patients with mild and localized hypertrophy may have severe symptoms,36 whereas other patients with . . .
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Maron et al. (1987) conducted a review in Hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy presents with symptoms like exertional angina and dyspnea, which do not always correlate directly with a single pathophysiologic mechanism or the magnitude of hypertrophy.
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