Hypertrophic cardiomyopathy presents with symptoms like exertional angina and dyspnea, which do not always correlate directly with a single pathophysiologic mechanism or the magnitude of hypertrophy.
This review highlights that while symptom severity in hypertrophic cardiomyopathy generally correlates with left ventricular hypertrophy magnitude, exceptions exist.
(Second of Two Parts)Interrelation between Pathophysiologic Mechanisms and Disease ManifestationsSymptomsThe chief symptoms of hypertrophic cardiomyopathy are exertional angina, dyspnea, fatigue, and impaired consciousness (transient spells of lightheadedness, near-syncope, and syncope). However, a direct, one-to-one correlation between a particular symptom and a single pathophysiologic mechanism does not always exist. For example, in a population of patients with hypertrophic cardiomyopathy, a general relation exists between the severity of symptoms and the magnitude of left ventricular hypertrophy19; however, this correlation is not absolute, and some patients with mild and localized hypertrophy may have severe symptoms,36 whereas other patients with . . .
Maron et al. (1987) conducted a review in Hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy presents with symptoms like exertional angina and dyspnea, which do not always correlate directly with a single pathophysiologic mechanism or the magnitude of hypertrophy.
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