Key result
In an experimental rat model, low-dose verapamil reduced triac-induced myocardial disarray and hypertrophy, whereas the calcium ionophore A23187 produced both disarray and hypertrophy when given alone.
Why the study?
Does modulating intracellular calcium with verapamil or A23187 affect triac-induced myocardial disarray and hypertrophy in developing rat hearts?
Population
Pregnant rats and developing rat hearts
Comparison
Verapamil or A23187 administered together with… vs Triac alone, or verapamil/A23187 administered…
Design
Preclinical
Authors
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Should not yet change practice; hypothesis-generating for calcium modulation in cardiomyopathy models.
Does modulating intracellular calcium with verapamil or A23187 affect triac-induced myocardial disarray and hypertrophy in developing rat hearts?
This experimental study suggests that increased intracellular calcium plays a key role in the pathogenesis of myocardial disarray and hypertrophy, potentially modeling hypertrophic cardiomyopathy.
Pearce et al. (1985) studied Hypertrophic cardiomyopathy. Verapamil and calcium ionophore A23187 vs. Triac alone was evaluated on Myocardial disarray and hypertrophy. In an experimental rat model, low-dose verapamil reduced triac-induced myocardial disarray and hypertrophy, whereas the calcium ionophore A23187 produced both disarray and hypertrophy when given alone.
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