Key result
Patients with hypertrophic cardiomyopathy had a 33% increase in atrial calcium-antagonist receptors compared to those with other cardiac disorders (397 vs 299 fmol/mg protein; P<0.01).
Population
16 patients with hypertrophic cardiomyopathy and 19 patients with various other cardiac disorders
Design
Case-control
Authors
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Atrial calcium-antagonist receptor upregulation was associated with hypertrophic cardiomyopathy; hypothesis-generating and should not yet change practice.
Observational (n=35)
Absolute Event Rate: 397% vs 299%
p-value: p=<0.01
The increased density of calcium-antagonist receptors in the atrial tissue of patients with hypertrophic cardiomyopathy suggests abnormal calcium fluxes may play a pathophysiologic role in the disease.
Wagner et al. (1989) conducted an observational in Hypertrophic cardiomyopathy (n=35). Hypertrophic cardiomyopathy vs. Various other cardiac disorders was evaluated on Density of calcium-antagonist receptors (fmol per milligram of protein) (p=<0.01). Patients with hypertrophic cardiomyopathy had a 33% increase in atrial calcium-antagonist receptors compared to those with other cardiac disorders (397 vs 299 fmol/mg protein; P<0.01).
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