Key result
Elevated perioperative BNP and lactate linked to higher 1-month mortality, prolonged ventilation, and longer ICU stays.
Why the study?
The predictive role of BNP and serum lactate in children undergoing cardiac surgery remains unclear, with contradictory results reported across prior studies.
Do serum levels of BNP and lactate predict morbidity and mortality in children with congenital heart diseases undergoing cardiac surgery?
Population
132 children who underwent cardiac surgery
Comparison
Serum BNP and lactate measured before, 24 h, and 72 h after surgery
Design
Prospective study
Follow-up
1-month
Authors
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May inform perioperative risk assessment in congenital heart surgery; hypothesis-generating and requires prospective validation before guiding care.
Cohort (n=132)
Do serum levels of BNP and lactate predict morbidity and mortality in children with congenital heart diseases undergoing cardiac surgery?
Elevated serum levels of BNP and lactate before and after cardiac surgery are significant predictors of morbidity and mortality in children with congenital heart disease.
Aval et al. (2025) conducted a cohort in Congenital heart disease requiring cardiac surgery (n=132). Brain natriuretic peptide (BNP) and serum lactate levels was evaluated on 1-month mortality rate, duration of ventilator connection, and duration of ICU admission. Elevated serum levels of BNP and lactate before and after cardiac surgery were significantly associated with increased 1-month mortality, longer ventilator duration, and prolonged ICU stay.
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