Key result
A risk model incorporating delta lactate and single ventricle status predicted early morbidity and mortality in neonates following cardiac surgery with good discrimination (AUC 0.79; 95% CI 0.75-0.89).
Why the study?
To evaluate the discriminative ability of hyperlactataemia for early morbidity and mortality following cardiac surgery in neonates with CHD.
Does hyperlactataemia predict early morbidity and mortality in neonates with congenital heart disease following cardiac surgery?
Population
432 neonates undergoing cardiac surgery on cardiopulmonary bypass at a tertiary care children's hospital
Comparison
Postoperative lactate levels and trajectories
Design
Retrospective observational study
Follow-up
30 days
Authors
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May aid postoperative risk stratification in neonates with CHD; leaves open whether lactate-guided interventions improve outcomes.
Observational (n=432)
No
Does hyperlactataemia predict early morbidity and mortality in neonates with congenital heart disease following cardiac surgery?
Delta lactate in the immediate post-operative period combined with single ventricle status can prognosticate the risk of early morbidity and mortality in neonates undergoing cardiac surgery.
Valencia et al. (2021) conducted an observational in congenital heart disease (n=432). Lactate levels (peak and delta) was evaluated on Composite of cardiac arrest or extracorporeal membrane oxygenation within 72 hours or 30-day mortality post-operatively. A risk model incorporating delta lactate and single ventricle status predicted early morbidity and mortality in neonates following cardiac surgery with good discrimination (AUC 0.79; 95% CI 0.75-0.89).
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