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March 1, 2009Circulation Heart FailureOpen Access

Small Animal Models of Heart Failure

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Population

Rodent models of heart failure

Design

Review

Authors

RPRichard D. PattenMHMonica R. Hall-Porter

Discussion

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Overview

Supports rodent model selection for HF preclinical studies; leaves open optimal translation to human disease.

Key Points

  • This review aims to discuss various small animal models of heart failure and their applications in evaluating treatments.
  • Describes commonly used heart failure models in rodents.
  • Reviews how these models evaluate novel therapies.
  • Summarizes chronic changes in myocardial structure and function.
  • Identifies key small animal models used in heart failure research.
  • Highlights examples of therapies tested in these models.
  • Demonstrates the progression of left ventricular dysfunction through these models.

Structured PICO

P
Population
Rodent models of heart failure

This review summarizes commonly used rodent models of heart failure for studying pathophysiology and evaluating novel therapies.

Cite This Study

Patten et al. (2009) studied this question.

synapsesocial.com/papers/6a09068762c780efd627fb73https://doi.org/10.1161/circheartfailure.108.839761
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