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July 1, 2025Scientific ReportsOpen Access

Association between glucose-to-lymphocyte ratio and mortality in patients with heart failure from the MIMIC-IV database: a retrospective cohort study

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Why the study?

The relationship between glucose-to-lymphocyte ratio and mortality among critically ill patients with heart failure admitted to the intensive care unit remains poorly understood.

Does an elevated glucose-to-lymphocyte ratio predict increased 30-day and 365-day mortality in critically ill patients with heart failure?

Population

14,417 patients with heart failure admitted to the ICU

Comparison

Varying GLR levels

Design

Retrospective cohort study

Follow-up

365 days

Authors

GWGang WuHKHung‐Lung KeZTZijia Tong

Discussion

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Member takes

Overview

GLR may aid risk stratification in critically ill HF but should not yet change practice; leaves open its incremental value over standard predictors.

Structured PICO

Does an elevated glucose-to-lymphocyte ratio predict increased 30-day and 365-day mortality in critically ill patients with heart failure?

P
Population
14,417 critically ill adult patients (age ≥ 18 years) with heart failure admitted to the intensive care unit (ICU), mean age 72.77, 55.75% male, from the MIMIC-IV database (Beth Israel Deaconess Medical Center, Boston, USA).
I
Intervention
High glucose-to-lymphocyte ratio (GLR > 143.35)
C
Comparator
Low glucose-to-lymphocyte ratio (GLR ≤ 143.35)
O
Outcome
30-day mortality and 365-day mortalityhard clinical

Elevated glucose-to-lymphocyte ratio is an independent predictor of increased 30-day and 365-day mortality in critically ill patients with heart failure.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/6a0908acbee8d5ab8a92db8dhttps://doi.org/10.1038/s41598-025-08349-9
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