Key result
Muscle LIM protein emerges as a potential therapeutic target for muscle atrophy via nuclear translocation.
Why the study?
It remains an open question what type of stress or mechanical strain induces anabolic events or mechanotransduction processes involved in muscle cell protein synthesis.
Design
Review
Authors
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MLP merits preclinical validation as atrophy target; leaves open clinical translation pending interventional trials.
Muscle LIM protein (MLP) plays a key role in mechanotransduction and may serve as a therapeutic target to counteract muscle atrophy.
Germain et al. (2022) conducted a review in Muscle atrophy and neuromuscular deconditioning. Muscle LIM protein (MLP) / Mechanotransduction was evaluated. Muscle LIM protein acts as a structural and mechanosensing protein that translocates to the nucleus during anabolic processes, presenting a potential therapeutic target for muscle atrophy.
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